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ALI & Pulmonary HA Deposition After SAH

Recruitingn/aAges 18 Years - 80 YearsAllTianjin Medical University
NCT06628531 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Acute lung injury is a common complication of subarachnoid hematoma (SAH), and a significant risk factor for death in patients with SAH. Unlike neurogenic pulmonary edema and pneumonia following brain injury, the clinical causes of pulmonary injury after SAH are not intracranial hypertension or pulmonary infection. Its occurrence is influenced by the release of catecholamines, the regulatory function of the hypothalamic-pituitary-adrenal (HPA) axis and systemic inflammatory response, but the specific mechanisms are still unclear. Therefore, delving into the pathological mechanisms of SAH-induced lung injury and developing therapeutic strategies based on the findings is of great importance to improve the prognosis of patients. Abnormal accumulation of hyaluronic acid in the lungs has been reported to be closely related to the pathological progression of various pulmonary injury diseases,

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age between 18 and 80 years old with independent behavior ability or authorized legal representative. * A documented diagnosis of SAH within 5 days. * A Hunt-Hess scale of Ⅳ or Ⅴ. * Absence of clinical and etiological evidence of pulmonary infection. Exclusion Criteria: * Pregnant or lactating women. * Present history of traumatic brain injury or intracranial hemorrhage. * Past history of neurological disorders, lung infection within the past six months, cancer, chronic cardiopulmonary diseases, hematological diseases or renal failure. * Have participated in clinical trials in the past 4 weeks. * The investigator considers that not appropriate for inclusion.
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What it tests

  • Not listed
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Where

1 site
Tianjin Medical University General Hospital
Tianjin, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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