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Effect of Modified Poco-Poco Exercise to Frailty Stages, Expression of Global DNA Methylation, GDF15 and Lamin A COP

RecruitingNAAges 60 Years - anyAllUniversitas Padjadjaran
NCT06628895 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to know the effect of multicomponent exercise in frail elderly in community to aging hallmarks. The main question\[s\] it aims to answer are: 1. Do global DNA methylation levels change in elderly people in Bandung after receiving modified poco-poco exercise? 2. Do GDF15 levels change in elderly people in Bandung after they are given modified poco-poco exercise? 3. Do lamin A COP levels change in elderly people in Bandung after they are given modified poco-poco exercise? 4. Does the level of frailty in elderly people in Bandung change after they are given modified poco-poco exercise? Participants will be asked to do flexibility, balance, aerobic and strengthening exercise included in poco-poco modified exercise three times a week for 12 weeks

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Frailty level is in pre-frailty 2. MoCA INA score above 18 3. Domicile in Bandung City 4. Willing to participate in the study after informed consent Exclusion Criteria: 1. There is a hearing impairment that may prevent the subject from receiving verbal instructions 2. There is uncorrected visual impairment 3. There are musculoskeletal disorders so that they cannot perform exercise procedures or procedures for measuring research variables 4. Subjects received other rehabilitation programs 5. Post-stroke with average limb muscle strength below three 6. There are diseases that cause impaired cognition such as Alzheimer\'s disease, traumatic head injury, Parkinson\'s disease. 7. There are severe joint diseases such as osteoarthritis and rheumatoid arthritis that may worsen during exercise or may cause difficulty in carrying out the exercise program. 8. Severe cardiovascular disease as assessed by a heart and vascular specialist 9. Unable to attend Exercises regularly
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What it tests

  • EXERCISE TRAINING WITH OR WITHOUT MEDICATION
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Where

1 site
Puskesmas Sekejati
Bandung, Indonesia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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