Targeting CD5 CAR-T Cells in the Treatment of r/r CD5+ T-ALL

Inclusion Criteria: * 1\. According to the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines for Acute Lymphocytic Leukemia (2020. v1), patients diagnosed as CD5+T-ALL; * 2\. Consistent with r/r CD5+T-ALL diagnosis, including any of the following conditions: 1. No CR after standard chemotherapy; 2. The first induction reaches CR, but CR ≤ 12 months; 3. Patients with r/r CD5+T-ALL have not responded to the first or multiple remedial treatments; c.Multiple recurrences. * 3\. CD5 expression rate was \>90%; * 4\. Number of blasts in the bone marrow (protolychic + larvae) \>5% (morphology) and/or \>1% (flow cytometry); * 5\. Total bilirubin ≤51 (mol/L), Alanine aminotransferase (ALT)/Aspartate aminotransferase (AST) ≤ 3 times the upper limit of the normal range, creatinine ≤176.8 (mol/L); * 6\. Echocardiography showed left ventricular ejection fraction (LVEF) ≥50%; * 7.Refers to the pulse oxygen saturation 92% or higher oxygen (state); * 8.Estimated life expectancy of minimum of 12 weeks; * 9.ECOG 0-2; * 10.Pregnant/lactating women, or male or female patients who have fertility and are willing to take effective contraceptive measures at least 6 months after the last cell infusion during the study period; * 11\. Those who voluntarily participated in this trial and provided informed consent; Exclusion Criteria: * 1.Patients with the history of epilepsy or other CNS disease; * 2\. Patients with prolonged QT interval time or severe heart disease; * 3\. Active infection of hepatitis B virus, C virus or hepatitis E virus; * 4\. Active infection with no cure; * 5\. Before using any gene therapy products; * 6\. Received anti-tumor therapy before infusion, should meet the following any one should be ruled out: 1. treated with systemic corticosteroids therapy within 72 hours (except glucocorticoid physiological replacement therapy, such as prednisone \< 10 mg/d or an equivalent dose of the drug); 2. received within 72 hours of small molecule targeted therapy; 3. 2 weeks received systemic chemotherapy except (pretreatment); 4. four weeks received radiotherapy; * 7\. The proiferation rate is less than 5 times response to CD3/CD28 co-stimulation signal; * 8\. Any unsuitable to participate in this trial judged by the investigator; * 9\. Any situation that researchers believe may increase the risk to the subjects or interfere with the trial results.