Evaluation of Effect of Platelet-Rich Fibrin on Orthodontic Tooth Movement: a Split Mouth Randomised Controlled Trial

Inclusion Criteria: * Patients who give written consent to participate in the research * Orthodontic patients with good oral hygiene * Patients with periodontal probing depths≤3 mm with no bone loss * Patients undergoing orthodontic treatment with fixed appliance and requiring upper first premolar extraction followed by canine retraction * Patients treated with canine retraction utilizing maximum anchorage in the maxillary arch from trans-palatal arch anchorage device * Patients with mild to moderate crowding in maxillary arch * Patients with no previous history of orthodontic treatment Exclusion Criteria: * patients who are smokers, health compromised (such as diabetics, with bone disorders, immunocompromised, known with blood dyscrasias) will be excluded from the trial. Patients with drug history of non-steroidal anti-inflammatory drugs, anti-inflammatory (in last 30 days), antibiotic therapy in last 3 months and those women who are pregnant will also be excluded. Other exclusion criteria will be patients with hypodontia, impacted/ectopic canines, extracted first molars, and patients who may discontinue the trial with or without assigning any reasons and those not consenting to participate in the research.