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Daptomycin vs. Vancomycin for the Treatment of Methicillin Resistant S. Aureus Bacteremia

RecruitingPhase 4Ages 18 Years - anyAllTodd C. Lee MD MPH FIDSA
NCT06637332 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is an open label randomized controlled trial for patients with methicillin resistant S. aureus (MRSA) bloodstream infection which will directly compare the two most commonly used therapies, vancomycin and daptomycin. This study is an approved sub-study of The Staphylococcus aureus Network Adaptive Platform (SNAP) trial (NCT05137119)

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📋 Eligibility rules (as published)
The participant must meet all inclusion and exclusion criteria for the SNAP Platform (NCT05137119) and also the following inclusion and exclusion criteria: Inclusion Criteria: * Methicillin-resistant S. aureus bacteremia Exclusion Criteria: * Severe allergy or non-severe rash to vancomycin or daptomycin * Suspected or confirmed MRSA pneumonia * Known vancomycin minimum inhibitory concentration (MIC) greater than or equal to 2mg/L or daptomycin MIC greater than or equal to 1mg/L
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What it tests

  • Daptomycin for Injection
  • Vancomycin (IV)
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Where

20 sites
Blacktown Hospital
Blacktown, Australia
Concord Repatriation and General Hospital
Concord, Australia
John Hunter Hospital
Newcastle, Australia
Westmead Hospital
Westmead, Australia
Royal Brisbane and Women's Hospital
Herston, Australia
Flinders Medical Centre
Bedford Park, Australia
Monash Health - Casey Hospital
Berwick, Australia
Box Hill Hospital
Box Hill, Australia

…and 12 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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