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PrEP Readiness Interventions for Sustained Motivation (PRISM)

RecruitingNAAges 18 Years - anyAllFlorida International University
NCT06637436 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a hybrid type I randomized controlled trial to test the effectiveness of contingency management (CM) alone versus CM with motivational interviewing (MI) for optimizing entry or re-entry into the HIV prevention or care continua. A total of 400 participants will be randomized to CM (n = 200) or MI+CM (n = 200), all delivered via telehealth. Monthly follow-up assessments will be completed over 12 months to examine effectiveness MI+CM for the primary outcome - filling a pre-exposure prophylaxis (PrEP) or anti-retroviral therapy (ART) prescription (verified using a digital photo). Secondary outcomes will include: self-reported PrEP or ART clinical evaluation by a provider; self-reported meth and other substance use severity (ASSIST), and self-reported receptive and insertive condomless anal sex (CAS).

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18 years or older * Assigned male a birth * Self-reported methamphetamine use in the past 3 months * HIV-negative or unknown serostatus at baseline * Has not filled a PrEP prescription in the past 6 months Exclusion Criteria: * Unwilling or unable to provide informed consent
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What it tests

  • Motivational Interviewing (MI)
  • Contingency Management (CM)
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Where

1 site
Florida International University
Miami, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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