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Sudden Cardiac Arrest Related to Sport in Young and Value of the Genetic Assessment: a French Prospective Register

Recruitingn/aAges 12 Years - 35 YearsAllRennes University Hospital
NCT06642168 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The increased risk of sudden cardiac arrest (SCA) or sudden cardiac death (SCD) related to vigorous physical activity is well-documented. Currently, for young victims (under 35 years) of SCA/SCD, no etiology is found in 40 to 50% of cases after a standard medical assessment, leading to two important consequences. For the victim's family, it is difficult to understand and accept this tragic event, and the risk of it occurring in another family member is a source of concern. Medically, the absence of a known cause limits the ability to effectively prevent such events. The RESOUDRE study will be a national, prospective, observational registry of young victims (12-35 years) of sports-related SCA/SCD. All cases will undergo the recommended etiological assessment, including autopsy for SCA cases, along with whole exome genetic analysis and toxicological testing. In the event a genetic patholo

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📋 Eligibility rules (as published)
Inclusion Criteria: * Victims of SCA: * Aged between 12 and 35 years * No known cardiovascular pathology * Experienced a sudden and non-traumatic SCA during or within one hour of participating in sports activities (leisure, training, or competition) * For resuscitated victims (SCA group): A person or legal representative who does not oppose participation in the research after being informed about the study (including individuals, organs, or authorities responsible for assisting or representing them if they are unable to express their wishes). * For non-resuscitated victims (SCD group): A person who has not formally objected to the reuse of their medical data during their lifetime. * First-Degree Relatives: * A person or legal representative who does not oppose participation in the research after being informed about the study (including individuals, bodies, or authorities responsible for assisting or representing them if they are unable to express their wishes). Non-Inclusion Criteria: * For resuscitated SCA cases, individuals weighing less than 20 kg * Victims or legal representatives who are subject to legal protection or deprived of their liberty
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What it tests

  • Whole exome sequencing to detect myocardial genetic mutations (SCA group only)
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Where

26 sites
CHU Nîmes
Nîmes, France
APHP Hôpital Bichat
Paris, France
APHP Hôpital Européen Georges Pompidou
Paris, France
CHU Rennes
Rennes, France
CHU Bordeaux
Bordeaux, France
CHU Brest
Brest, France
CHU Caen
Caen, France
CHU Clermont-Ferrand
Clermont-Ferrand, France

…and 18 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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