Ablative Radioembolization of Renal Cell Carcinoma Trial

Inclusion Criteria: * Patients willing to participate and provide written consent * Patients 18 years of age and older * Eastern Cooperative Oncology Group (ECOG) performance status (PS) ≤2 * Biopsy confirmed RCC \&gt; 4.0 cm and no renal vein or IVC involvement (T1b or T2 disease) * Not suitable for or declining standard of care nephrectomy or partial nephrectomy * Adequate hepatic function, defined by the following laboratory results: * Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5 × upper limit of normal (ULN) (or ≤5 × ULN if presence of liver metastases) * Total bilirubin ≤3 × ULN * Serum albumin ≥3.0 g/dL unless prothrombin time (PT) is within the normal range * Adequate hematologic function, defined by the following laboratory results: * Hemoglobin concentration ≥8.0 g/dL * Absolute neutrophil count (ANC) ≥1000 cells/µL (≥1000 cells/mm3 ) * Platelets \>50 × 109 /L (100 × 103 /mm3 ) * For women of childbearing potential (WOCBP): * Negative serum pregnancy test within 48 hours prior to the first dose of study treatment * Agreement to use barrier contraception and a second form of highly effective contraception (Clinical Trials Facilitation Group \[CTFG\] 2020) while receiving study treatment and for 7 months following their last dose of study treatment. Alternatively, total abstinence is also considered a highly effective contraception method when this is in line with the preferred and usual lifestyle of the subject. Periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception. * Sexually active male subjects must use a condom during intercourse while receiving treatment and for at least 120 days after the last dose of the study treatment and should not father a child during this period. * Male study subjects whose sexual partners are WOCBP must also agree to use a second form of highly effective contraception (CTFG 2020) while receiving 90Y and for at least 4 months following their last dose. Alternatively, total abstinence is also considered a highly effective contraception method when this is in line with the preferred and usual lifestyle of the subject. * Vasectomized men are also required to use a condom during intercourse, including with a male partner, to prevent delivery of the drug via seminal fluid. Exclusion Criteria: * Evidence of metastatic disease on CT or MRI * Severely impaired renal function (GFR ≤ 30 mL/min/1.73m²) and not on dialysis * Bilateral RCC without plan for definitive therapy of the contralateral lesion * RCC that is locally recurrent at prior surgery or ablation site (new location in same or contralateral kidney is permitted) * Prior or concurrent kidney radiation therapy or systemic immunotherapy/TKI * Lung shunt with estimated lung radiation dose \&gt; 30 Gy for single dose or \&gt; 50 Gy total. * Planning angiogram cone beam CT from all accessible feeding arteries shows lack of perfusion to all or portions of the RCC tumour such that, in the investigator's opinion, Y-90 radioembolization would result in substantial RCC tumour being untreated or receive an inadequate dose. * Contraindication to arterial renal angiogram, or both CT and MRI contrast medium * History of severe allergy to CT contrast medium or any study product ingredients that cannot be managed medically * History of chronic lung disease with baseline oxygen saturation \< 90% or requiring home oxygen therapy. * Congestive heart failure with ejection fraction \< 40% * Presence of active infection, defined by the investigator as clinically significant. * Any chronic condition that is severe or unstable and, in the opinion of the investigator, would put the patient at unacceptable risk of adverse event related to the Y-90 radioembolization procedure. Such conditions include but are not limited to: unstable angina, congestive heart failure, interstitial lung disease, severe gastrointestinal disease with diarrhea. * Life expectancy \&gt; 1 year * Pregnant or breast-feeding patient