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Efficacy and Safety of Add-on Timolol for EGFR-TKI and ALK-TKI Induced Paronychia

RecruitingPhase 3Ages 18 Years - anyAllQueen Mary Hospital, Hong Kong
NCT06643416 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

To assess the clinical efficacy of add-on topical timolol 0.5% eye drops to betamethasone valerate 0.1% for the treatment of EGFR-TKI and ALK-TKI induced paronychia.

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📋 Eligibility rules (as published)
Inclusion criteria 1. Aged 18 years or above, either males or females. 2. Received EGFR-TKI and ALK-TKI, namely gefitinib, erlotinib, afatinib, osimertinib, amivantamab, dacomitinib, mobocertinib, crizotinib, ceritinib, alectinib, brigatinib and lorlatinib for the treatment of non-small cell lung cancer. 3. Paronychia (fingernails, toenails, or both) as an adverse event from EGFR-TKI use 4. Written informed consent obtained from patient 5. Subjects are diagnosed with advanced non-small cell lung cancer Exclusion criteria 1. 1\. Age below18 2. 2\. Patients who are allergic to, or contraindicated to topical timolol use 3. 3\. Pregnant women or nursing mother 4. 4\. Non-consenting patients 5. 5\. Subjects are not diagnosed with advanced non-small cell lung cancer
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What it tests

  • Timolol 0.5% eye drops and betamethasone valerate 0.1% cream
  • Betamethasone valerate 0.1% cream
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Where

1 site
Queen Mary Hospital
Hong Kong, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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