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Is Non Surgical CaRE Using Treat to Target Multimodal meDIcal Strategies aBLE to Delay or Avoid Total Knee Replacement?

RecruitingNAAges 18 Years - 90 YearsAllUniversity Hospital, Brest
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In plain words

What the trial is, and whether it could suit you

Knee is the most common site of osteoarthritis. Treatment of knee osteoarthritis starts with a full course of medical therapy, followed by surgery to replace the knee with a prosthesis if this strategy fails, or in advanced cases. However, the new recommendations of the French rheumatology society, which evaluate the various treatments and position them in the treatment plan, are not well known, and the definition of a complete treatment remains unclear. The vast majority of patients are therefore referred to a surgeon after having tried a small part of the therapeutic arsenal (generally analgesics and corticosteroid or hyaluronic acid infiltrations). The goal of this study is to to select patients most likely to gain from surgery and to develop strategies that avoid the need for major surgery.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18-90 years old * Femoro-tibial osteoarthritis Kellgren stage stage≥ 2 without laxity in extension; * A proposal of total knee replacement by a surgeon; * No corticosteroid joint injection within 3 months; * Visual analogic score pain (VAS) \>40/100 but \<90/100 or Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index function sub scale \>40/100 at inclusion; * Wish to discuss medical care; * Able to consent and having signed a consent form. Exclusion Criteria: * Contraindication or no indication to surgery or medical care (severe infection for example) * Inflammatory arthritis * Lack of social insurance * Symptomatic (VAS pain \>40) contralateral knee or hip osteoarthritis (with or without replacement) * Pregnant or breastfeeding woman * Patient under court protection, guardianship, curatorship * Patient deprived of liberty
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What it tests

  • arthroplasty
  • Medical and non-medical treatments
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Where

21 sites
CHU Amiens
Amiens, France
CHU Brest
Brest, France
CHU Caen
Caen, France
CHD Vendée
La Roche-sur-Yon, France
CHU Le Mans
Le Mans, France
CHU Limoges
Limoges, France
GHICL- Hôpital Saint Philibert
Lomme, France
HCL
Lyon, France

…and 13 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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