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Progesterone-modified Natural Cycle for FET

RecruitingPhase 3Ages 21 Years - 44 YearsFemaleShandong University of Traditional Chinese Medici…
NCT06644794 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Hormone replacement therapy (HRT) cycles, despite the ease of synchronizing embryo thawing and embryo transfer timing, increase the risk of pregnancies and obstetric complications compared to natural cycles (NC). By ensuring the presence of the corpus luteum while reducing the number of monitoring sessions, the progesterone modified natural cycle (P4mNC) offers more convenience for the patient than the normal NC. This study is designed to compare the effects of P4mNC and HRT cycles on FET outcomes.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged 21 to 44 years undergoing FBT * Body mass index (BMI) 18-35 kg/m2 * Having regular ovulatory cycles Exclusion Criteria: * Untreated uterine adhesions * Medical contraindications to estrogen and progesterone therapy * Illnesses contraindicating assisted reproductive technology or pregnancy * History of recurrent implantation failures (\> 2 embryo transfer failures)
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What it tests

  • Progesterone-modified natural cycle preparation for frozen embryo transfer
  • Hormone replacement therapy cycle preparation for frozen embryo transfer
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Where

1 site
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Jinan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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