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Liposomal Bupivacaine and Bupivacaine for TTMPB in Median Sternotomy

RecruitingNAAges 18 Years - 90 YearsAllTongji Hospital
NCT06646172 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In light of the ongoing controversy surrounding the efficacy of bupivacaine liposomes, our study was designed to investigate, for the first time, the differential postoperative analgesic effects between bupivacaine liposomes combined with bupivacaine hydrochloride and bupivacaine hydrochloride alone in transverse thoracic muscle plane block treatment. The aim is to provide evidence-based medical guidance for drug selection in regional block local anesthesia.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged 18-90 years; * ASA Class I \~ III; * Patients undergoing elective median sternotomy. Exclusion Criteria: * Emergency surgery; * Re-operation; * Coagulation dysfunction; * Preoperative left ventricular function was poor (ejection fraction \<35%); * Systemic infection or injection site infection; * Neuromuscular diseases; * Mental illness; * Dependence on psychotropic drugs; * Allergic to bupivacaine liposomes and bupivacaine; * Patients have participated in previous trials or have been determined by a surgeon or anesthesiologist to be unsuitable for randomization; * Failure to obtain written informed consent from the patient or his/her representative
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What it tests

  • Transverse thoracic muscle plane block (TTMPB) using liposomal bupivacaine and bupivacaine mixture
  • Transverse thoracic muscle plane block (TTMPB) using bupivacaine hydrochloride
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Where

1 site
Tianzhu Liu
Wuhan, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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