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Childhood B-acute Lymphoblastic Leukaemia and Role of CD9 Gene Regulation in Relapse

RecruitingNAAges 0 Years - 17 YearsAllRennes University Hospital
NCT06649253 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

B-acute lymphoblastic leukaemia (B-ALL) is the most common cancer in children, with 20% of patients relapsing. CD9, a transmembrane protein, is linked to the migratory and adhesion capacities of leukaemia cells and could be associated with relapses. The aim of this project is to understand how CD9 regulation can be a marker of potential relapses, using bone and blood sampling of newly diagnosed patients at 3 crucial moments of therapy.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Under 18 years * With established diagnosis of B-ALL * Initial diagnosis made in the investigating centre * Having received oral and written information about the protocol, or oral only if the patient is unable to read. * Having signed a consent form if the patient is capable of giving informed written consent. * Whose legal guardians have received oral and written information about the protocol, and have signed a free, informed and written consent. * Beneficiary of a social security scheme Exclusion Criteria: * Isolated extramedullary involvement at inclusion * Patient of childbearing age without effective contraception. * Adult subject to legal protection (safeguard of justice, curatorship, guardianship), person deprived of liberty.
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What it tests

  • Sampling bone tissue and blood
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Where

3 sites
CHU Angers
Angers, France
CHU Brest
Brest, France
CHU Rennes
Rennes, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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