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AlEX-DHF: Ablation and Exercise in Diastolic Heart Failure

RecruitingNAAges 18 Years - 99 YearsAllTechnical University of Munich
NCT06650995 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The investigators analyze the impact of exercise and ablation in patients with symptomatic short-persistent atrial fibrillation (Afib) and heart failure with preserved ejection fraction (HFpEF). It is hypothesized that the combination of ablation and exercise better improves peak oxygen consumption (VO2peak) through improvement of peripheral (exercise training) and central (ablation) adaptations. Exercise intervention will contain a 12-week combined, video-based, supervised, endurance, resistance and respiratory training.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosed heart failure with preserved ejection fraction * Symptomatic short-persistent atrial fibrillation (diagnosis within 1 year of study inclusion) Exclusion Criteria: * Paroxysmal, long-persistent or permanent atrial fibrillation * Clinically unstable coronary artery disease or acute coronary syndrome * Physical and/or mental inability to perform exercise testing * Prior ablation therapy * Precapillary pulmonary hypertension at rest * Intracardiac shunts * Left ventricular ejection fraction \<50% * High-degree valve insufficiency or stenosis (greater than grade 1 at rest)
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What it tests

  • Exercise training
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Where

1 site
Department of Medicine, Division of Prevention and Sports Medicine TU Munich
Munich, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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