Algorithm-based Management to Reduce the Recurrence of GI Bleeding and Severe Epistaxis in Von Willebrand Disease

Inclusion Criteria: * Males and females adults aged \> 18 years * With a constitutional von Willebrand Disease (according to the phenotypic criteria of the French Reference Center of von Willebrand Disease) * With a GI bleeding \[either overt (any hematemesis, any melena or hematochezia with at least a 2g/dL drop in hemoglobin) or occult (iron deficiency anemia with at least 2g/dL drop in hemoglobin)\] with the presence of angiodysplasia or a negative finding on digestive conventional endoscopy OR with a severe epistaxis (requiring red blood cells transfusion or treatment with VWF concentrates) * Be affiliated to a social security scheme * Written informed consent obtained Exclusion Criteria: * Acquired von Willebrand Disease * Presence of an inhibitor to VWF or a contra indication to VWF concentrates * Contra-indication to videocapsule endoscopy * Refusal of the procedures part of the study * Pregnant women or breastfeeding * Short-life expectancy * Liver cirrhosis Child-Pugh C or diagnosed portal hypertension * Cancer currently undergoing chemotherapy * Inability to provide informed consent * Patient under justice protection