Rifaximin and Cardiac Function in Patients with Heart Failure with Preserved Ejection Fraction

Inclusion Criteria: 1. availability of written informed consent of the patient to participate in the study 2. adult aged ≥18≤80 years' old 3. body mass index ≥25 kg/m2 4. diagnosed with HFpEF: 1) symptoms and/or signs of heart failure; 2) left ventricular ejection fraction ≥50%; 3) increased levels of natriuretic peptides (NTproBNP≥125 pg/mL); 4) at least one additional criterion: relevant structural heart disease (hypertrophy of the left ventricle (LVH) and/or enlargement of the left atrium (LAE) or diastolic dysfunction Exclusion Criteria: 1. refusal of the patient from further participation in the study 2. identification of any disease or condition specified in the criteria for non-inclusion and the development of a severe pathological condition in which patient monitoring becomes poorly implemented and the presence of which may make it difficult to interpret the data (gastrointestinal bleeding, myocardial infarction, etc.)