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Influence of Healing Time on the Outcomes of Alveolar Ridge Preservation in Periodontally Compromised Extraction Sockets

RecruitingNAAges 18 Years - anyAllShanghai Ninth People's Hospital Affiliated to Sh…
NCT06654141 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to histologically, clinically, and radiographically evaluate the healing sequelae of periodontally compromised extraction sockets grafted with Bio-Oss Collagen® at 3 and 6 months following tooth extraction in molar sites. The main question it aims to answer is: Does healing time influence the histologic, clinical, and radiographic outcomes following socket grafting (alveolar ridge preservation) in periodontally compromised extraction sockets. Researchers will compare a healing time of 3 months to a healing time of 6 months (conventional healing duration) to see if a shorter duration is viable for implant placement. Participants will: Take a cone-beam computed tomography (CBCT) scan to prepare for the surgical procedure. Undergo tooth extraction and the extraction socket will be grafted with Bio-Oss Collagen® and a collagen membrane Bio-Gide® will b

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18 years of age or older * ASA (American Society of Anesthesia) status I or II * Need for molar extraction due to periodontal disease with or without chronic endodontic involvement, complying with the presentation of periodontitis stage III/IV * Radiographic evidence of a bone dehiscence on at least one socket wall, where the height of the horizontal (suprabony) component of the defect (alveolar bone crest - cement-enamel junction) is \>50% of the corresponding root length as measured on CBCT scans prior to extraction (Ben Amara et al., 2021) * Radiographic evidence of at least 3 mm of residual bone wall height * Presence of at least one adjacent tooth to the extraction site * Treatment plan must include tooth replacement with an implant-supported fixed dental prosthesis Exclusion Criteria: * Extraction of multiple adjacent teeth * Acute infection associated with the tooth to be extracted or with adjacent teeth * Current smokers (\>10 cigarettes per day) * Uncontrolled diabetes mellitus (HbA1c \>7.0) * Any active oral or systemic acute infections * Currently receiving chemo- or radiotherapy or a history of radiotherapy in the head and neck area * Diseases or medications that may compromise normal wound healing
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What it tests

  • Alveolar ridge preservation
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Where

1 site
Shanghai Ninth People's Hospital
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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