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FAPI Imaging Assessment of Chronic Total Occlusion

Recruitingn/aAges 18 Years - anyAllLin Zhao
NCT06655922 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This registry will include consecutive patients presenting with at least one chronic total coronary occlusion (CTO) identified via coronary angiography or cardiac computed tomography angiography (CCTA) at our center. Due to the complexity of CTO lesions, both procedural success rates and prognosis improvements are limited. The progression and development of atherosclerotic plaques involve fibroblast activity, contributing to the formation of fibrous caps and calcified nodules through various mechanisms. Myocardial fibrosis within chronically occluded segments is strongly linked to ventricular remodeling and patient prognosis. The activation of cardiac fibroblasts (CFs) is a critical early phase in myocardial fibrosis, playing a key role in fibrotic progression. However, the role of activated CFs in CTO patients has remained unclear, mainly due to the lack of reliable in vivo assessment t

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \> 18 years * Presence of at least one untreated CTO at basal angiography (defined as a total occlusion in any major coronary vessel or relevant side branches \[reference vessel diameter ≥2.5mm or as judged by two independent interventional cardiologists\], with TIMI 0 in the distal segment and at least 3 months old * Patient has a clinical indication to perform CTO PCI * Willing to participate and able to understand, read and sign the informed consent document. Exclusion Criteria: * Hypersensitivity to aspirin, clopidogrel, or -limus families / or contraindication to antiplatelet agents * Severe hepatic dysfunction (≥3 times normal reference values) * Severe chronic kidney disease (estimated Glomerular Filtration Rate \[eGFR\] \<30 mL/min/1.73m2) * Life expectancy \< 1 years * Pregnant women or women with potential childbearing
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What it tests

  • FAPI Imaging
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Where

2 sites
Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Beijing, China
Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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