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โ† Trials
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Use of Transcranial Magnetic Stimulation in the Post-Operative Cognitive Dysfunction in Elderly

RecruitingNAAges 60 Years - 120 YearsAllUniversity of Sao Paulo General Hospital
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In plain words

What the trial is, and whether it could suit you

Postoperative Cognitive Dysfunction (POCD) is a prevalent condition with significant clinical, social, and financial impacts on patients and healthcare services. The term POCD refers to any signs of new cognitive impairment that exceed the expected time for recovery from the acute effects of surgery and anesthesia. Mild Cognitive Impairment (MCI) is among the main risk factors and is defined as a small cognitive decline from the previous level of performance in one or more cognitive domains, without interfering with daily activities. Considering the aging population linked to an increase in the number of individuals with MCI and a growing demand for surgery, the identification of interventions that can prevent the occurrence of POCD is necessary. Non-invasive brain stimulation (NIBS) techniques such as TMS (Transcranial Magnetic Stimulation) are widely used in research and clinical pract

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Patients over 60 years old 2. Patients scheduled for elective surgeries of moderate or large scale and candidates for general or spinal anesthesia; 3. Patients who demonstrate possible or probable cognitive impairment based on pre-operative screening using the 10-CS (10-point cognitive screening) tool; - For Non-surgical Control Intervention Group, only the first and third criteria will be applied. Exclusion Criteria: 1. Contraindications for the use of Transcranial Magnetic Stimulation (metal implants in the head, history of seizures or epilepsy, brain trauma or surgery, intracranial hypertension, and complications from exposure to magnetic fields); 2. Medical diagnosis of Major Neurocognitive Disorder (any form of dementia, regardless of the stage); 3. Indication for skull surgery; 4. Conditions that interfere with cognitive testing (presence of severe hearing and vision loss, inability to understand Portuguese); 5. Ongoing medication adjustments that affect cortical electrical activity (antidepressants, antipsychotics); 6. Difficulty attending treatment during the stipulated evaluation and follow-up period, whether due to socioeconomic or clinical reasons; 7. Anticipation of surgical scheduling;
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What it tests

  • Theta Burst Stimulation
  • Theta Burst Stimulation Sham
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Where

1 site
University of Sao Paulo
Sรฃo Paulo, Brazil
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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