AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

โ† Trials
๐Ÿงช

Abbreviated Magnetic Resonance Imaging vs Ultrasound Surveillance for Liver Cancer dETection in People at High Risk of Developing Liver Cancer

Recruitingn/aAges 18 Years - anyAllUniversity of Oxford
๐Ÿ’ฌ

In plain words

What the trial is, and whether it could suit you

Aim: To use magnetic resonance imaging (MRI) scans without contrast to help improve diagnosis of liver cancer in people who are at increased risk of developing liver cancer. Background: People with any condition that affects the liver over a long period of time can develop cirrhosis. Conditions and risk factors that can lead to cirrhosis include alcohol excess, liver steatosis (lipid or fat accumulation in the liver) and infection with the viruses hepatitis B and C. One of the concerns about people with cirrhosis is that they are at increased risk of developing liver cancer. People with cirrhosis are recommended to have an ultrasound scan (USS) every 6 months (surveillance for liver cancer) so that if a cancer develops, it is diagnosed at an early stage when it can be cured. However, ultrasound can miss cancers even in people having scans every 6 months. Furthermore, the risk of cancer

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * โ€ข Participant is willing and able to give informed consent for participation in the study AND * All genders, aged 18 years or above AND * Eligible for HCC US surveillance in the opinion of the local investigators AND * Child Pugh score A or B AND * Diagnosed with liver cirrhosis due to ArLD, MASLD, chronic hepatitis C, chronic hepatitis B, genetic haemochromatosis AND * Have an annual risk of HCC of at least 3% as determined by the aMAP score OR * Participants with chronic liver disease (with or without cirrhosis) who had successful treatment for HCC, have not had a recurrence and have returned to 6 monthly surveillance with USS Exclusion Criteria: * โ€ข Contraindication to MRI * Known allergy / reaction to intravenous gadolinium contrast * Prisoners * Pregnancy or breast feeding * Previous liver transplant * Participants who are known to have indeterminate liver nodules on prior imaging requiring ongoing follow-up with MRI or CT * Previous HCC treated with curative intent and still being followed up with CT or MRI with contrast for possible recurrence * Estimated glomerular filtration rate of \<30 ml/min/1.73m2 * Participant is on haemodialysis * Participants who are unlikely to comply with the study procedures in the opinion of the local investigator * In the view of the clinician, if the participant has a co-morbidity likely to lead to death within the following 12 months
๐Ÿ’Š

What it tests

  • non contrast enhanced MRI
๐Ÿ“

Where

2 sites
Oxford University Hospitals NHS Foundation Trudt
Oxford, United Kingdom
Bournemouth University Hospital
Bournemouth, United Kingdom
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy