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Treating Loneliness In The Older Adult With Depression With tDCS

RecruitingNAAges 60 Years - 80 YearsAllGuangzhou Psychiatric Hospital
NCT06658795 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

High loneliness is prevalent among older adults and is a significant risk factor for major depression and low recovery rates in patients. Current interventions for loneliness are limited. Previous research has demonstrated a link between loneliness, negative social emotions, and reduced resting-state functional connectivity in the lateral prefrontal cortex (LPFC) and the default mode network (DMN). Transcranial direct current stimulation (tDCS) has shown promise in enhancing emotional regulation and connectivity, potentially alleviating loneliness in older adults with depression.

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📋 Eligibility rules (as published)
Inclusion Criteria: * High loneliness (UCLA Loneliness Scale \> 43). * Diagnosis of major depressive disorder confirmed by the Structured Clinical Interview for DSM-5 Disorders. * absence of suicidal ideation (Hamilton Depression Scale item 3 score ≤ 1). Exclusion Criteria: * Severe neurological diseases. * Bipolar disorder, schizophrenia, addiction, or impulse control disorders. * Contraindications for tDCS or MRI (e.g., metal implants). * Presence of suicidal ideation.
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What it tests

  • Transcranial direct current stimulation (tDCS) on the Left DLPFC
  • Transcranial direct current stimulation (tDCS) on the right VLPFC
  • Sham stimulation group
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Where

1 site
Guangzhou Brain Hospital
Guangzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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