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Prevention of Mother-to-child Transmission (PMTCT) Among Women Experiencing Depression in Malawi

RecruitingNAAges 18 Years - anyAllUniversity of California, San Francisco
NCT06659315 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Prevention of mother-to-child transmission (PMTCT) of HIV virtually eliminates transmission of HIV from mothers to their infants. Adherence to PMTCT (i.e., to antiretroviral therapy, infant prophylaxis, and exclusive breastfeeding) during pregnancy and the postpartum period is challenging, with evidence from sub-Saharan Africa (SSA) showing suboptimal adherence and persistent viremia among perinatal women. Perinatal depression (PD) is a major driver of women's poor adherence to PMTCT. Interventions that involve male partners to provide social and food/economic support could be a promising approach for addressing PD and PMTCT, yet few interventions have intervened with couples to improve systems of support, communication, and other dyadic processes. The investigators propose to develop and test a couple-based approach to intervene on the mother's perinatal depressive symptoms and to stren

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📋 Eligibility rules (as published)
Inclusion Criteria: * In a marriage or cohabitating union for at least 6 months. * One member of the couple is a woman in the second or third trimester of pregnancy who is living with HIV and screens positive for depression (\>10 on the PHQ9). * Have revealed their HIV status to their partner if living with HIV\> Exclusion Criteria: * Fear their safety would be at risk. * Report incidents of severe intimate partner violence (IPV) in the past three months using the WHO IPV measure.
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What it tests

  • Couples Problem Solving Therapy
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Where

1 site
Invest in Knowledge (IKI)
Zomba, Malawi
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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