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Heart Attack Blood Oxygen Therapy Trial

RecruitingNAAges 18 Years - anyAllNHS National Waiting Times Centre Board
NCT06662890 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

'Heart attack', known as acute ST-segment elevation myocardial infarction, is a leading cause of heart failure and death. A lack of blood and oxygen damages the heart muscle potentially causing heart failure and premature death. During the past 25 years, despite intensive research efforts, few, if any new medicines have been shown to prevent heart failure after a heart attack. New treatment approaches are needed. The standard treatment for a heart attack is for a doctor to reopen the blocked blood vessel. The treatment is called primary percutaneous coronary intervention, or 'primary PCI'. The doctor places a thin plastic tube in a blood vessel in the wrist. The doctor then passes a longer thin tube via the wrist into the blocked heart artery. A small balloon is then used to open the blockage and a thin metal tube (stent) is placed inside the blood vessel to keep it open. The patient t

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age ≥18 years. 2. Ischemic time ≤6 hours from symptom onset 3. Acute anterior ST-segment elevation myocardial infarction 4. Infarct-related left anterior descending coronary artery TIMI flow grade 2-3 at the end of PCI 5. Radial artery access 6. Partial pressure of oxygen (PaO2) \>80 mmHg (10.7 kPa) Exclusion Criteria: 1. Proximal coronary artery stenosis that restricts blood flow with the SSO2 catheter in place 2. Post-PCI non-stented dissection or perforation. 3. Moderate - severe heart valve stenosis, insufficiency, pericardial disease, or non-ischaemic cardiomyopathy 4. Known pregnancy. 5. Cardiogenic shock 6. Contra-indication to anticoagulation 7. Acute mechanical complication e.g., ventricular septal rupture, pseudoaneurysm, mitral regurgitation 8. Hemoglobin \<10 g/dL 9. Major bleeding or major surgery within the past two months 10. Contra-indication to cardiovascular magnetic resonance (CMR) imaging e.g., severe claustrophobia, metallic foreign body. 11. Lack of witness verbal consent.
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What it tests

  • Supersaturated oxygen
  • Sham (No Treatment)
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Where

1 site
Golden Jubilee National Hospital
Clydebank, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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