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Chronic Anergic Depression IDentification - Magnetic Resonance Imaging Exploration in the Elderly of Traits Related to Onset

RecruitingNAAges 60 Years - 90 YearsAllUniversity Hospital, Strasbourg, France
NCT06663891 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Depression in the elderly, or "late life depression" (LLD), is often considered to be homogeneous, legitimizing standardized treatment. Yet the literature suggests that there are different forms of LLD, with different pathophysiology, course and treatment. Our experience has led us to identify an "anergic" form, marked by adynamia and anhedonia (anergic depression, AnD). Highly represented among LLDs, it readily resists the usual antidepressants, so that its course is often chronic. Thanks to the "Chronic Anergic Depression Open Trial", the investigators were able to show that AnD responds to dopaminergic (DA) molecules. Therefore the invastigators hypothesized a pathophysiology linked to dysfunction of the mesolimbic DA system. However, not all patients would present the same form: two subgroups could be isolated, each contributing equally. The first corresponds to patients for whom t

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient aged 60 (inclusive) to 90 years (exclusive) * Patient presenting with active or remitted anergic depression according to the operational criteria of the "Chronic Anergic Depression Open Trial" (1) confirmed by two psychiatrists involved in the study: * Early Onset Depression (EOD) group: with at least one history of depression before age 60 * Late Onset Depression (LOD) group: no history of depression before age 60 * Patient able to understand the objectives/risks of the research and give informed consent * Patient affiliated to a health insurance social protection scheme, beneficiary or dependent Exclusion Criteria: * Contraindication to an MRI scan (including claustrophobia)\* * Psychiatric or organic comorbidity that may interfere with the interpretation of results (e.g. neurovascular disease, psychotic disorder, proven neurodegenerative disease) * Concomitant treatment that may interfere with the interpretation of results (e.g. interferons, corticosteroids) * Patient in exclusion period (from a previous or current study) * Current protective measure (curatorship, guardianship) * Patient under legal protection \* presence of non-removable ferromagnetic foreign body, prosthesis, pacemaker, defibrillator, neurostimulation device, medications delivered by an implanted pump, vascular clip or stent, heart valve or ventricular shunt, implanted device incompatible with 3 Tesla MRI exam, claustrophobia, epilepsy
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What it tests

  • Functional MRI with EEG per MRI
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Where

1 site
Hôpitaux Universitaires de Strasbourg
Strasbourg, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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