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Stereotactic Radiotherapy of Prostate Cancer With Reduction of Safety Margins

RecruitingNAAges 18 Years - anyMaleUniversity Hospital Ostrava
NCT06665932 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The study aims to reduce the PTV (Planning Target Volume) safety margins to 1-2 mm in stereotactic prostate radiotherapy for low- and medium-risk prostate cancers while maintaining a dose of 36.25 Gy in 5 fractions per day. By reducing the hems, the investigators expect a reduction of acute and late toxicity on the organs at risk, dominantly the urethra, bladder, penile bulb, and rectum, and an improvement in the quality of life.

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📋 Eligibility rules (as published)
Inclusion Criteria: * histologically verified, localized prostate cancer without regional lymphadenopathy or distant metastases * low or intermediate risk - favorable risk * staging according to NCCN recommendations: * low risk: no staging required * intermediate risk- favorable risk: CT abdomen and pelvis * PSA up to 15 * age over 18 years * signed informed consent form * suitable position of fiducials (to be determined by the physicist) Exclusion Criteria: * a histological type other than acinar adenocarcinoma * the presence of local lymphadenopathy or distant metastases * a dominant lesion in the periphery that is in contact with the capsule or grows through it * PSA over 15 * unsatisfactory position of fiducials (to be determined by the physicist) * previous treatment with radiotherapy to the pelvic area
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What it tests

  • Stereotactic radiotherapy
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Where

1 site
University Hospital Ostrava
Ostrava, Czechia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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