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multipaRameter mOnitoring systeM for sedAtion iNThe ICu

Recruitingn/aAges 18 Years - anyAllPontificia Universidad Catolica de Chile
NCT06667869 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The administration of sedation in Intensive Care Units (ICU) is a vital and complex task, essential for the well-being of critically ill patients. Proper dosing is crucial, as both under-dosing and overdosing have adverse consequences for patients, including risks such as accidental extubation, ventilator disconnections, delirium, prolonged ventilation, ICU stays, and even increased mortality. Monitoring sedation levels is essential to maintain a balance in sedative administration. Clinical scales (RASS/SAS) are currently used as the reference method, but they have limitations. These scales may be inadequate when the patient is unresponsive or when neuromuscular blockers are used. An alternative is electroencephalography (EEG)-based monitors, though they also have limitations in accurately representing the level of hypnosis. The proposal is to develop an advanced multiparameter system

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients admitted to adult critical care units * Individuals over 18 years old * Requiring sedation for more than 24 hours * Patients needing mechanical ventilation for more than 24 hours Exclusion Criteria: * Patients with neurological pathology as the cause of mechanical ventilation (including recovered cardiocirculatory arrest, fulminant liver failure, and neurocritical conditions, except subdural hematomas or subarachnoid hemorrhages). * Pregnancy * Presence of psychiatric or intellectual disability prior to hospitalization * Drug dependency * History of chronic liver damage with hepatic encephalopathy * Second period of mechanical ventilation during hospitalization * Early limitation of therapeutic effort * Patients under 18 years old
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What it tests

  • Sedative
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Where

2 sites
Hospital Dr. Sotero del Rio
Santiago, Chile
Hospital Clínico Pontificia Universidad Católica de Chile
Santiago, Chile
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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