The Intensive Care Platform Trial

The general eligibility criteria below apply to INCEPT as a whole and thus to all domains. Domains may impose domain-specific eligibility criteria that restrict the population eligible for that domain further, but domains are not allowed to broaden the general eligibility criteria. Domain-specific eligibility criteria always apply to all arms in a domain. PLATFORM INCLUSION CRITERIA: * Adult patient (≥18 years old) acutely admitted to the ICU. This includes ICU admissions after emergency surgery, unplanned ICU admissions after elective surgery, and prolonged ICU admissions due to complications after elective surgery (i.e., admissions occurring or being prolonged due to an unexpected, worsened condition, but excluding planned ICU admissions after elective surgery without clinical deterioration). * Eligible for at least one active domain. PLATFORM EXCLUSION CRITERIA: * Informed consent following inclusion expected to be unobtainable (e.g., known previous objections to participation). * Patient is under coercive measures (e.g., ongoing involuntary hospital stay or under the jurisdiction of correctional authorities). Patients who have previously been included in INCEPT may only be included again during new ICU admissions but may only be randomised to domains in which they have not previously been randomised. DOMAIN-SPECIFIC ELIGIBLE CRITERIA: Each domain may have additional eligibility criteria. Refer to the study website for more information (www.incept.dk).