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Contribution of Multicenter Expertise and Deformable Fusion Software for Re-irradiations With Curative Intent

RecruitingNAAges 18 Years - anyAllCentre Leon Berard
NCT06668038 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

We propose to evaluate the contribution of a standardized process combining, * a validation of re-irradiation indications by a group of multi-professional experts (radiotherapists and physicists) and, * a collective validation of the accumulation of doses on all the organs of the anatomical region concerned obtained using deformable fusion software (MiM) allowing the accumulation of doses in terms of Equivalent Dose 2 Grays (EQD2). The primary objective of this study is to determine the rate of patients for whom this process has changed the treatment plan.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 18 years when signing the consent form * Re-irradiation with desired curative intent (≥ 50 Gy EQD2), with volume to be irradiated totally or partially included in a previous irradiation field: * Oligo-metastases or oligo-progression (\< 5 metastases in less than 3 sites) * Second cancer * Isolated local recurrence * Life expectancy \> 6 months * Dated and signed informed consent * Affiliation to a social security scheme or equivalent Exclusion Criteria: * Indication of intracranial, prostate, rectum or esophagus re-irradiation * Diagnosis of multi-metastatic cancer * PS ECOG ≥ 2 * Impossibility to interrupt current treatment with a tyrosine kinase inhibitor or other systemic treatment (excluding hormonal therapy) which may potentiate the rays effects (duration of wash-out according to treatment instructions) * Pregnant or breastfeeding women * Tutorship or curatorship or deprivation of liberty
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What it tests

  • Multidisciplinary and multicenter validation of re-irradiation with curative intent
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Where

10 sites
Institut de Cancerologie de L'Ouest
Angers, France
Ch Bourg En Bresse
Bourg-en-Bresse, France
Centre Georges Francois Leclerc
Dijon, France
Chu Grenoble Alpes
Grenoble, France
Centre Leon Berard
Lyon, France
Aphp Marseille Chu Timone Et Hopital Nord Marseille
Marseille, France
Centre Antoine Lacassagne
Nice, France
Institut de Cancerologie de L'Ouest
Saint-Herblain, France

…and 2 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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