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Inhibitory Control Training and iTBS for Excess Weight: Behavioral and Brain Changes (InhibE).

RecruitingNAAges 18 Years - 60 YearsAllRaquel Vilar López
NCT06668077 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

People with excess weight (EW) are characterized by high impulsivity, high levels of craving for high-calorie foods, deficits in inhibitory control, and maladaptive decision-making. These characteristics are related, at the brain level, to alterations in the activation of areas such as the dorsolateral prefrontal cortex (DLPFC) and its connectivity. The proposed intervention seeks to target these issues. Thus, the present study aims to characterize the effects of neuromodulation with intermittent theta burst transcranial magnetic stimulation (iTBS) of the DLPFC alone and in combination with inhibitory control training to produce brain, cognitive and behavioral changes, and modify altered biological parameters in people with EW. Participants will be randomly allocated to one of three groups: (1) a group that will receive active iTBS of the DLPFC combined with inhibitory control training w

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📋 Eligibility rules (as published)
Inclusion Criteria: * BMI between 25 and 39.9 * Age between 18 and 60 years * Proficiency in the Spanish language * Right lateral dominance to avoid differential effects due to cortical hemispheric specialization Exclusion Criteria: * Traumatic, digestive, metabolic or systemic disorders that affect the central nervous system, autonomic or endocrine * Severe psychopathological disorders and suicidal ideation or treatment for depression * Eating disorders * Contraindication for performing fMRI (pregnancy, metal implants, etc.) or iTBS (tinnitus, dizziness, surgical interventions, diseases or drugs that affect the CNS, etc.)
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What it tests

  • iTBS of the left DLPFC
  • iTBS of the vertex
  • Inhibitory control training
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Where

1 site
Mind, Brain and Behavior Research Center at University of Granada (CIMCYCUGR)
Granada, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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