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Does Co-administration of Lactate Affect Postprandial Nutrient Absorption and Fat Disposition?

RecruitingNAAges 50 Years - anyAllUniversity of Aarhus
NCT06668714 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Aim To investigate the effects of oral lactate administration on nutrient absorption and substrate utilization in individuals with pre-diabetes. Hypothesis The addition of lactate to a meal improves postprandial lipemia and reduces lipid storage in ectopic tissues through delayed absorption and faster removal of circulating lipids from circulation.

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📋 Eligibility rules (as published)
Inclusion Criteria: * 50+ years * Written and oral consent * HbA1c 39-47 mmol/L Exclusion Criteria: * Medicine with an impact on blood glucose and glucose metabolism. * Newly started medicine (\<3 months prior to the inclusion time) * Medicine changes (\<3 months prior to the inclusion time and planned changes during the trial) * Affected screening blood sample as evaluated by PI * Hba1c \> 47 * Allergy to paracetamol * Doesn't speak or understand Danish * Special diets The eight healthy individuals will be included by the same criteria except for not having pre-diabetes
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What it tests

  • Placebo + mixed meal
  • Lactate + mixed meal
  • PET-scan
  • Mixed meal with 18F-FTHA
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Where

1 site
Aarhus University Hospital
Aarhus, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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