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Effects of Real vs. Soundless Acoustic Stimulation During Deep Sleep on Brain Activity, Memory, and Blood Biomarkers in Older Adults (60-85) With Mild Memory Impairment

RecruitingNAAges 60 Years - 85 YearsAllUniversity of Bern
NCT06669546 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to explore a non-invasive way to improve memory and slow cognitive decline in older adults by enhancing sleep quality. Dementia, a leading cause of death worldwide, is often associated with disturbed sleep, particularly the loss of deep, slow-wave sleep (SWS). SWS is important for memory and clearing waste from the brain. Poor SWS can worsen memory loss and allow harmful waste to build up, which may increase the risk of dementia. The investigators are testing whether phase-locked auditory stimulation (PLAS) can improve SWS in people at a mild stage of cognitive impairment. PLAS uses short sounds played at specific moments to strengthen slow-wave brain activity during sleep. The investigators previous laboratory based research has shown that this can improve memory and help with clearing waste from the brain. Now, the investigators want to test this in a real-world settin

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📋 Eligibility rules (as published)
Inclusion Criteria: * Written informed consent * Age between 60 and 85 years * Cognitive impairment (subjective and/or MoCA between 23-26) * Native German speakers or comparably fluent * Normal or corrected-to-normal vision. * Intact hearing * A close cohabitant (partner/sibling) should be present to support participants in using study materials/devices. Exclusion Criteria: * Insomnia assessed by the Regensburg Insomnia Scale (RIS; Crönlein et al., 2013) * Restless leg syndrome assessed by questions concerning typical symptoms. * Sleep apnoea assessed by the Berlin Questionnaire (BQ; Netzer et al., 1999) * Severely irregular sleep patterns assessed by the RIS and the Pittsburgh sleep quality index (PSQI; Buysse et al., 1989) * Symptoms of depression (Geriatric Depression Scale (GDS; Yesavage et al., 1982) ≥ 5) * History of untreated severe neurological and psychiatric diseases * Alcohol or substance abuse * Use of medication acting on the central nervous system
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What it tests

  • Phase-locked auditory stimulation (PLAS)
  • Sham Phase-Locked Auditory Stimulation
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Where

1 site
University Hospital of Old Age Psychiatry and Psychotherapy, University of Bern
Bern, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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