Efficacy of an Amine and Zinc Lactate - Containing Mouthrinse in the Home-based Treatment of Plaque-induced Gingivitis in Adolescents.

Inclusion Criteria: * systemically healthy; * eligible for oral care provision by Regional Health Service due to low socio-economic status; * at least 16 fully erupted teeth (excluding third molars); * diagnosed with plaque-induced gingivitis (G) or periodontal health (PH) according to the World Workshop case definitions (Trombelli et al. 2018, Chapple et al. 2018); * willing to participate in the study and capable to fully understand and comply with the study procedures (including questionnaire reading and filling). Exclusion Criteria: * pregnant or lactating; * current smoking; * motor and/or cognitive deficit impairing compliance with the study intervals or procedures; * legal guardian not willing to either allow for subject participation in the study or ensure adherence with the study procedures; * teeth with developmental defects (e.g., enamel pearls/projections); * untreated oral lesions, including dental caries or endodontic lesions; * fixed or removable orthodontic appliances or scheduled for orthodontic therapy with a timing not compatible with the experimental phase; * use of antibiotics in the previous 3 months; * use of medications that affect the size of the gingival tissues, such as phenytoin, sodium valproate, certain calcium channel-blocking drugs (e.g., nifedipine, verapamil, diltiazem, amlodipine, felodipine), and immune-regulating drugs (e.g., cyclosporine); * conditions (e.g., Sjögren's syndrome, anxiety, poorly controlled diabetes) or medications (e.g., antihistamines, decongestants, antidepressants) that are associated with hyposalivation.