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Haplo-HSCT for Myelofibrosis

RecruitingNAAges any - anyAllPeking University People's Hospital
NCT06674382 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Myelofibrosis (MF) is a myeloproliferative neoplasm causing bone marrow failure and high risk of leukemia transformation. JAK2 inhibitors improve symptoms but do not cure MF. Allogeneic stem cell transplantation (allo-HSCT) is the only potential cure, though limited donor availability restricts access. Haploidentical transplantation shows promise but associated with higher graft failure and treatment related mortality. We recently developed a novel regimen of haplo-SCT for MF. This study aims to investigate this novel protocol in a prospective trial to improve MF outcomes.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Primary disease type: Myelofibrosis (including primary myelofibrosis and myelofibrosis secondary to polycythemia vera or essential thrombocythemia). * No matched sibling donor or unrelated donor, with the availability of a haploidentical donor. * Signed informed consent. Exclusion Criteria: 1. Active infection 2. Very poor performance status (ECOG score \> 2) 3. Estimated survival time \< 30 days 4. Patient or family unable to cooperate 5. Considered unsuitable after discussion
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What it tests

  • Haploidentical hematopoietic stem cell transplantation
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Where

1 site
Peking University People's Hospital
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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