Natural History of Uncommon Dyslipidemias, Rare Lipid Disorders and Unusual Atherosclerotic Conditions

* INCLUSION CRITERIA: Affected Participants * Male and female participants age \>= 10 years. * Subjects with confirmed or suspected rare disorder that causes lipid/lipoprotein abnormalities (dyslipidemia) or abnormal documented or referred atherosclerosis patterns. * Only affected individuals (not healthy volunteers and for self-referred subjects independent of lipid and lipoprotein marker values.); subjects with laboratory or clinical presentation that in the opinion of the Principal Investigator, would alter the determination of normal parameters for assays and screening tools development. -Ability of the subject or Legally Authorized Representative (LAR) to understand and willingness to sign a written informed consent document. Healthy Volunteers * Participants must be healthy, with no known history of lipid disorders or related medical conditions. * Participants must not be pregnant. EXCLUSION CRITERIA: * Patients with disorders that cause common secondary/lipoprotein alterations. * Patients with any other findings that, in the opinion of the Principal Investigator, would preclude them from participating in the study.