🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Benzydamine Hydrochloride and Post-operative Sore Throat

RecruitingEARLY Phase 1Ages 21 Years - 80 YearsFemaleKK Women's and Children's Hospital
NCT06676748 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Postoperative sore throat (POST) after laryngeal mask airway (LMA) insertion is prevalent and unappealing. A significant cause of POST is mechanical injury to the airway mucosa during airway instrumentation, leading to mucosal injury and inflammation. The Difflam Forte Anti-Inflammatory Throat Spray (Difflam) contains benzydamine hydrochloride, a non-steroidal anti-inflammatory agent with topical analgesic properties. This study will randomize 106 women undergoing gynaecological surgery under general anaesthesia with LMA use at KK Women's and Children's Hospital (KKH) in 1:1 allocation ratio of study (Difflam spray) and control (usual practice; no intervention) groups. Demographic and intraoperative airway data collection will be conducted in perioperative period. Those allocated to study group will receive Difflam spray when awake in the post-anaesthesia care unit (PACU). The primary ai

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: 1. American Society of Anaesthesiologists (ASA) physical status 1-2 2. Female patients having laryngeal mask airway (LMA) for airway management for surgery in KKH; 3. BMI \< 40 kg/m2. Exclusion Criteria: 1. Pregnant; 2. Pre-existing sore throat, or history of upper respiratory tract infection/ abnormalities, hypertension, chronic pain or anti-inflammatory drugs and antihypertensive treatment; 3. Allergies to benzydamine hydrochloride; 4. Symptomatic hiatus hernia; 5. Severe gastroesophageal reflux disease; 6. Contraindications to the use of LMA.
💊

What it tests

  • Benzydamine Hydrochloride
📍

Where

1 site
KK Women's and Children's Hospital
Singapore, Singapore
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy