Effect of Intranasal Oxytocin on Emotion Recognition and Acute Psycho-Social Stress-induced Cortisol Increase in Patients With Central Diabetes Insipidus and Healthy Controls

Inclusion criteria healthy controls 1. Adult healthy volunteers 2. Matched for age, sex, BMI, and oestrogen replacement/menopause/hormonal contraceptives to patients. 3. No medication, except hormonal contraception Inclusion criteria 1. Adult patients with a confirmed diagnosis of AVP deficiency based on accepted criteria6 2. Stable hormone replacement therapy for at least three months with desmopressin and, in case of additional anterior pituitary deficiencies, with the respective substitution therapies. Exclusion criteria 1. Participation in a trial with investigational drugs within 30 days 2. Active substance use disorder within the last six months 3. Consumption of alcoholic beverages \>15 drinks/week 4. Current or previous psychotic disorder (e.g., schizophrenia spectrum disorder) 5. Pregnancy and breastfeeding within the last eight weeks