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Establishment of a Microfluidic Based Liquid Biopsy Platform for Recurrent/Metastatic Head and Neck Cancers Prognostication Using NK Cell IFN-ฮณ Expression and CTM Correlation With DS-SACA Chip

Recruitingn/aAges 20 Years - anyAllNational Taiwan University Hospital
NCT06678724 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to learn about the prognostic value of circulation tumor emboli (CTM) in recurrent/metastatic head and neck cancer patients and also the changes of tumor microenvironment by different treatment modalities and drugs. The main questions it aims to answer are: 1. Investigators plan to correlate circulating tumor cells (CTC), circulating tumor emboli (CTM), and the composition of NK cells in CTM with clinical outcomes and establish their association with patient prognosis. 2. Investigators plan to understand the composition of NK cells and the immune cell components within CTM, and correlate these findings with treatment efficacy. Patients with recurrent/metastatic head and neck cancer will be included after informed consent and investigators will collect blood samples for analysis from them under the treatment provided by their primary care physicia

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: must fulfill with all the items below * Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0-2. * \>=20 years old. * had pathologically confirmed squamous cell carcinoma of the oropharynx, oral cavity, hypopharynx, or larynx that was recurrent or metastatic and not curable by local therapy. * had at least one tumor lesion measurable per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 * Medical records during treatment are available. Exclusion Criteria: * Medical records during treatment unavailable * Could not cooperate with blood sampling * Without informed consent
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What it tests

  • Not listed
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Where

1 site
National Taiwan University HsinChu Branch
Zhubei, Taiwan
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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