๐ŸŒ EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

โ† Trials
๐Ÿงช

Surgical Treatment of Peri-implantitis With Adjunctive Application of Platelet Rich Fibrin (PRF)

RecruitingNAAges 18 Years - anyAllUniversity of Bern
NCT06679283 on ClinicalTrials.gov โ†—
๐Ÿ’ฌ

In plain words

What the trial is, and whether it could suit you

Platelet-rich fibrin (PRF) is a second-generation platelet concentrate used for tissue and bone regeneration. PRF releases growth factors such as TGF-ฮฒ, PDGF, VEGF, IGF, and FGF, which are known to promote wound healing and bone regeneration. Thus, PRF may offer a promising therapeutic approach for peri-implantitis treatment. Numerous studies have reported beneficial effects of PRF on bone regeneration, bone augmentation, soft tissue healing, and ridge preservation. In infrabony periodontal defects, PRF has shown significant improvements in pocket depth reduction, clinical attachment level (CAL) gain, and bone fill. However, a recent systematic review highlighted that evidence supporting PRF use in peri-implantitis remains limited, primarily due to a lack of adequately designed studies. Therefore, the aim of this project is to investigate whether PRF enhances regeneration in peri-implan

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. One or more peri-implant sites with PPD โ‰ง 5 mm combined with BOP/suppuration and 2. Peri-implant marginal bone loss, defined as a crater like defect โ‰ง 3 mm as assessed from intraoral radiographs 3. Good oral hygiene i.e. a plaque index \<20% 4. Written informed consent Exclusion Criteria: 1. History of chronic inflammatory disease 2. Severe systemic diseases 3. Medically confirmed diagnosis of diabetes mellitus 4. Anti-inflammatory prescription including prednisone 5. Smoking \> 5 cigarettes 6. Pregnant or lactating women 7. \< 18 years of age
๐Ÿ’Š

What it tests

  • Open flap debridement with a chemo-electric device + PRF
  • Open flap debridement with a chemo-electric device alone (control)
๐Ÿ“

Where

1 site
Department of Periodontology, University of Bern
Bern, Switzerland
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy