Fibrinolysis Resistance in Infection and Trauma

Sepsis/Septic shock Inclusion Criteria: * Admission to ICU, needing at least one organ supportand principally for the management of clinically suspected Sepsis or Septic shock according to Spesis-3 criteria (including SARS-COV-2) * Expected to remain in ICU and survive beyond the day after tomorrow Sepsis Exclusion Criteria: * On oral anticoagulant/antiplatelet therapy * Not for full, active ICU support * Death is deemed inevitable within 24 hrs Trauma Inclusion Criteria: * Trauma is the principal diagnosis on ICU admission * Expected to remain in ICU and survive beyond the day after tomorrow * Receiving respiratory support at the time of ICU admission - high-flow nasal prongs, non-invasive or invasive ventilation * Already received, or considered at risk of needing a blood product transfusion within 24 hrs of injury Trauma Exclusion Criteria: * Nursing home resident * Unsurvivable head injury * Not for full, active ICU support * Death is deemed inevitable within 24 hrs