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FeNO Observation Study in ICU Patients With ARS

Recruitingn/aAges 18 Years - 80 YearsAllShanghai Zhongshan Hospital
NCT06680895 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

1. Main Objective: To compare the concentration of exhaled nitric oxide in patients with different severity of respiratory failure in ICU. 2. Secondary Purpose: 1. To observe the change of nitric oxide concentration in exhaled breath of patients with mechanical ventilation over time; 2. The relationship and differences between pulmonary ventilation blood flow levels in patients with different exhaled NO concentrations; 3. Reactivity of patients with different exhaled NO concentrations to inhaled nitric oxide therapy and the relationship between them.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Adult patients (≥18 years of age) with mechanical ventilation or advanced respiratory support in the ICU, regardless of gender; 2. The expected mechanical ventilation time of tracheal intubation is more than 24 hours; 3. The initial ventilator Settings of clinical routine were adopted: oxygen fraction (FIO2) = 50%, respiratory rate = 15/min, positive end-expiratory pressure (PEEP) = 5 cmH2O, tidal volume = 6-8 ml/kg ideal body weight (IBW), inspiration-exhalation ratio =1:2; 4. Agree to participate in this experiment and sign the informed consent. Exclusion Criteria: * 1.Use of any NO-containing drugs (such as nitroglycerin), anti-inflammatory drugs, or drugs or means that affect the airway diameter within 6 hours before the first FeNO measurement; 2. Participating in other clinical research projects; 3. Patients deemed unsuitable by the investigators.
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What it tests

  • FeNO Observation
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Where

1 site
Shanghai Zhongshan hospital
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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