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Pediatric Positive End Expiratory Pressure (PEEP) Titration Using Electrical Impedence Tomography (EIT)

RecruitingNAAges 0 Years - 18 YearsAllChildren's Hospital Los Angeles
NCT06684119 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to perform a PEEP titration protocol and use EIT to identify the optimal PEEP at which lung overdistention and collapse are most effectively balanced. The primary and secondary aims of the study are as follows: Identify the difference between the optimal PEEP recommended by EIT metrics and the current guideline recommended approach to identifying optimal PEEP in PARDS. There will be a statistically significant difference in the recommended optimal PEEP identified using the EIT PEEP titration tool and that of the PEEP/FiO2 grid recommendations. Determine the difference in physiologic metrics between EIT optimal PEEP and the PEEP/FiO2 recommended PEEP. Participants will undergoing EIT monitoring while being subjected to PEEP titration protocol.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Any person who is less than 18 years of age * is on invasive mechanical ventilation * is not spontaneously breathing * meets PARDS criteria Exclusion Criteria: * Contraindication to the use of EIT * Hemodynamic instability * Contraindications to hypercapnia * patients with uncuffed endotracheal or tracheostomy tubes * diagnosis of pneumothorax or bronchopleural fistula * non-conventional ventilation * any patient on extra-corporeal membrane oxygenation (ECMO) support * less than 1 week post-operatively from cardiac surgery * the following cardiac diagnoses: Glenn or Fontan physiology, significant right to left shunt * Corrected Gestational Age \< 37 weeks * pregnancy
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What it tests

  • Electrical Impedance Tomography positive end-expiratory pressure titration
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Where

1 site
Children's Hospital Los Angeles
Los Angeles, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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