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Efficacy of Nerve Block Versus Botox in Chronic Migraine Management

RecruitingNAAges 18 Years - 65 YearsAllZagazig University
NCT06684249 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to determine whether nerve block injections (specifically, supratrochlear and greater occipital nerve injections) are as effective as Botulinum toxin A (Botox) injections in treating chronic migraine in adults. The main questions it aims to answer are: * Do nerve block injections reduce the number of monthly migraine days compared to baseline? * Are there any differences in the frequency of migraine-related symptoms between the nerve block and Botox treatment groups? * Which treatment leads to higher patient satisfaction and improved quality of life? Participants in this study will: * Receive either nerve block injections or Botox injections every 12 weeks. * Visit the clinic once every month for follow-ups and assessments. * Maintain a headache diary to record the frequency and severity of their migraines and any adverse effects experienced. * Rese

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged 18 to 65 years. * Diagnosis of chronic migraine, defined as having headaches on 15 or more days per month for more than three months, with at least 8 of those days meeting criteria for migraine. * Ability to provide informed consent and comply with study requirements. * No changes in prophylactic migraine medications in the last 3 months. Exclusion Criteria: * History of allergy or hypersensitivity to local anesthetics or Botulinum toxin. * Previous nerve block or Botox treatment within the last 6 months. * Significant comorbid psychiatric or neurological disorders that could interfere with study participation or evaluation. * Pregnancy or breastfeeding. * Contraindications to either treatment as per product labels.
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What it tests

  • Nerve Block Injections
  • Botulinum Toxin A
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Where

1 site
Zagazig University, Faculty of Medicine
Zagazig, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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