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Comparison of Pulsed and Thermal Radiofrequency for Trigeminal Neuralgia

RecruitingNAAges 18 Years - 60 YearsAllZagazig University
NCT06684275 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to compare the effectiveness of Pulsed Radiofrequency (PRF) with Pulsed and Thermal Radiofrequency (PRF + TRF) in treating Trigeminal Neuralgia (TN) in adults. The main questions it aims to answer are: * Does PRF or PRF + TRF provide better pain relief for patients with trigeminal neuralgia? * What is the safety profile and complication rate of PRF versus PRF + TRF? Researchers will compare the effects of PRF and PRF + TRF to see if thermal lesioning in addition to pulsed RF provides superior long-term pain relief and reduces the need for analgesic medication. Participants will: * Undergo either PRF or PRF + TRF treatment targeting the trigeminal nerve. * Be assessed for pain relief, functional status, and adverse events over a 3-month follow-up period.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults aged 18-60 years. * Diagnosis of classical trigeminal neuralgia, as per the International Classification of Headache Disorders criteria * Patients experiencing unilateral, episodic facial pain for at least six months with a Numeric Rating Scale (NRS) score greater than 6, despite medical treatment. * Able to provide informed consent. * Agree to follow the study procedures and attend follow-up visits. Exclusion Criteria: * Patients with secondary trigeminal neuralgia (e.g., due to tumors, multiple sclerosis). * Previous surgery or radiofrequency treatment for trigeminal neuralgia. * Pregnant or breastfeeding women. * Known allergies to anesthetics or other agents used in the procedure. * Significant psychiatric disorders that may interfere with pain assessment or study participation. * Coagulopathy or use of anticoagulants that contraindicate the procedure.
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What it tests

  • Pulsed Radiofrequency (PRF)
  • Pulsed and Thermal Radiofrequency (PRF + TRF)
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Where

1 site
Zagazig University, Faculty of Medicine
Zagazig, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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