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Cognitive Control During Sleep: the Strange Case of Self-Awakening

Recruitingn/aAges 18 Years - 65 YearsAllIRCCS San Raffaele
NCT06685380 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The experimental model of self-awakening highlights several important issues, particularly the lack of a reliable model for estimating the time interval, from minutes to hours, that passes between falling asleep at night and the moment of self-awakening. This may be explained by limited knowledge of ultradian brain oscillators (i.e., biorhythms with periods shorter than 24 hours) related to the perception of time during nighttime sleep, although the processes involved in the internal timing of circadian rhythms have been extensively studied. These are biologically regulated by a relatively small group of around 10,000 neurons in the suprachiasmatic nucleus of the hypothalamus, oscillating with a 24-hour rhythm. Little is known about ultradian timekeepers of sleep, especially related to the REM (Rapid Eye Movement) sleep cycle, but they likely play a crucial role in self-awakening. So fa

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📋 Eligibility rules (as published)
Inclusion Criteria: * Subjects, both men and women * aged over 18 and under 65 * Ability to understand and sign the informed consent Exclusion Criteria: * Subjects unable to read, understand, or correctly complete the procedures required by the study * Subjects with significant respiratory disorders (respiratory failure, pneumopathy, pneumothorax, COPD-Chronic Obstructive Pulmonary Disease) and sleep-related respiratory disorders (OSA-Obstructive Sleep Apnea Syndrome, central apneas) * Subjects with nocturnal epilepsy, epilepsy, REM (Rapid Eye Movement) and NREM (Non-Rapid Eye Movement) parasomnias * Subjects with neurological and/or psychiatric disorders * Subjects with any form of senile dementia * Subjects with significant internal medical conditions that could impair sleep, at the discretion of the study physician (diabetes, arterial hypertension, thyroid disorders, metabolic syndrome)
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What it tests

  • Not applicable- observational study
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Where

1 site
UO Neurologia Centro di Medicina del sonno
Milan, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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