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Convergent Mechanisms Underlying Reprometabolic Syndrome in Women

RecruitingPhase 2Ages 18 Years - 38 YearsFemaleUniversity of Colorado, Denver
NCT06686537 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Dr. Nanette Santoro proposes to test the specific question that obesity results in abnormal estradiol response at the level of the pituitary and hypothalamus. This will be shown in diminished pituitary sensitivity to gonadorelin releasing hormone with a reduced estradiol induced luteinizing hormone surge in obese women.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18-38 * Regular menstrual cycles every 25-35 days * No use of reproductive hormones within the past 3 months * No use of medications interacting with reproductive hormones * Agreement to use reliable barrier contraception or to abstain from intercourse for the duration of the study * Normal thyroid stimulating hormone, prolactin and lipid profiles * No more than 4 hours of moderate to vigorous intensity exercise per week * No history of chronic disease impacting reproductive hormones * No contraindications to administration of estradiol * No history of estrogen dependent cancer * Negative pregnancy test Exclusion Criteria: * Has diabetes * Is a smoker * History of venous thromboembolism or known thrombophilia
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What it tests

  • Estradiol Patches
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Where

2 sites
University of Colorado School of Medicine
Aurora, United States
University of Colorado-School of Medicine
Aurora, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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