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High Intensity Interval Training and Insulin Sensitivity in Type 2 Diabetes

RecruitingNAAges 45 Years - 75 YearsAllFinis Terrae University
NCT06688461 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A recognized driver for cardiovascular complications of type 2 diabetes mellitus (T2DM) is impaired plasma glucose homeostasis as consequence of skeletal muscle insulin resistance. Insulin-mediated plasma glucose disposal in skeletal muscle comprises oxidative glucose disposal (cellular glucose uptake for oxidation) and non-oxidative glucose disposal (NOGD; cellular glucose uptake for storage as glycogen), both processes being impaired in T2DM patients. Excessive intrahepatic fat accumulation (particularly monounsaturated (MUFA) and saturated (SFA)) is commonly observed in T2DM patients and tightly associates with plasma glucose dysregulation. It has been hypothesized that skeletal muscle insulin resistance redistributes circulating glucose away from muscle which together with hyperinsulinemia promotes intrahepatic lipid accretion via de novo lipogenesis (DNL). As saturated lipids is the

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📋 Eligibility rules (as published)
Inclusion Criteria: * Participants are able to provide signed and dated written informed consent prior to any study specific procedures * Aged ≥ 45 and ≤ 75 years * BMI: 25-35 kg/m2 * Diagnosed as T2DM patients for at least 1 year and not longer than 5 years * HbA1c ≥ 6.5% and ≤ 8.5% * Fasting blood glucose \<130 mg/dL * Women are post-menopausal (\>1 year cessation of menses), * Being stable on medication use of metformin and/or sulfonylurea derivatives for the previous 3 months or more and other medication naïve. Exclusion Criteria: * Type 1 diabetes * Patients with congestive heart failure and and/or severe renal and or liver insufficiency * Contraindications for MRI/MRS examination * Active diabetic foot * Polyneuropathy or retinopathy * Signs of active liver or kidney dysfunction * BMI \>35 kg/m2 * Exogeneous insulin therapy * Use of antidiabetic medication other than metformin or sulfonylurea derivatives treatment within 3 months before screening * Use of SGLT2 inhibitors * Unstable body weight (variations \>5kg in the last 3 months) * Ongoing weight loss diet or use of weight loss agents * Uncontrolled hypertension * Engagement in regular exercise program or any other medical condition that will impede the safe performance of the experiments
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What it tests

  • Experimental group: Exercise training
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Where

1 site
Finis Terrae University
Santiago, Chile
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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