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E-cigarette Cessation in Adults Who Co-use Cannabis

RecruitingPhase 4Ages 18 Years - 40 YearsAllMedical University of South Carolina
NCT06688539 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to better understand tobacco outcomes using a commonly prescribed stop smoking medication (varenicline) and financial incentives for adults who also use cannabis. Varenicline is not FDA approved for e-cigarette cessation, but is FDA approved for cigarette cessation. Investigators are also interested in how cannabis/marijuana and tobacco interact during a tobacco quit attempt. All participants will receive e-cigarette cessation treatment for 12 weeks. To qualify, participants must be between the ages of 18-40 and use both e-cigarettes and cannabis. Participants do not need to be interested in quitting cannabis to qualify. This study is being conducted at three sites: the Medical University of South Carolina in Charleston, SC, Behavioral Health Services in Pickens, SC, and MUSC Lancaster in Lancaster, SC.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Between the ages of 18 and 40 years old * Use e-cigarettes daily or near daily in the past month * Must submit a positive instant-read urine cotinine test at screening (≥ 200 ng/ml) * Be interested in quitting use of e-cigarettes * Must be willing to take varenicline for the standard 12-week course of treatment * Self-reported use of cannabis on at least 10 out of the past 30 days or must submit a positive qualitative urinary cannabinoid test at screening (\> 50 ng/ml) Exclusion Criteria: * Any serious or unstable medical/psychiatric disorder (including severe substance use disorders, other than cannabis or tobacco use disorders) in the past three months that may interfere with study performance * Use of cigarettes on 10+ days in the past 30 * Currently pregnant or breastfeeding * Current use of medications with smoking cessation efficacy * Use of any medications that would interfere with varenicline
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What it tests

  • Varenicline Pill
  • Contingency management
  • Counseling
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Where

3 sites
MUSC Charleston
Charleston, United States
MUSC Lancaster
Lancaster, United States
Behavioral Health Services of Pickens County
Pickens, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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