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Correlation of Typical LBBB Mechanical Activation Pattern by 2D Strain Echocardiography With Acute GWE Improvement in Patients Receiving LBBp or Conventional BiVp for Cardiac Resynchronization Therapy (Echo LBBp)

RecruitingNAAges 18 Years - 90 YearsAllUniversity Hospital of Patras
NCT06689111 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The present study is a multicenter interventional non randomised study in patients requiring an implantable device for cardiac resynchronization therapy. Its primary objective is to investigate whether the presence of a specific echocardiographic contraction pattern before implantation is associated with increased rates of acute improvement in myocardial function (as measured by an ultrasound) and to compare the improvement in two groups of patients based on the type of pacing (biventricular or left-sided pacing)

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📋 Eligibility rules (as published)
Inclusion Criteria: * \>18 years \< 90 years * Patients with a documented indication for resynchronization therapy \[symptomatic patients despite optimal medication, HFrEF (EF\<35%), LBBB QRS morphology\] * COMPLETE LBBB (LBBB defined as QRS\>130msec, wide "notched or slurred" R wave in leads I, aVL, V5, V6 and occasional RS pattern in V5, V6, absence of Q waves in leads I, V5 and V6 but in lead aVL narrow Q wave may be present in the absence of myocardial pathology, R peak time \>60ms in leads V5 and V6 but normal in leads V1, V2, V3 when small R's are discernible in precardial leads, ST and T usually opposite to QRS direction) * Patients with ntraventricular septum diameter \>8 mm * Written informed consent Exclusion Criteria: * Patients with RBBB or atypical LBBB QRS morphology * Patients eligible for an upgrade procedure (already carring a PM or ICD) * Patients with hypertrophic cardiomyopathy
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What it tests

  • Left bundle branch pacing lead
  • CRT with the standard method through cs
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Where

1 site
University Hospital of Patras
Pátrai, Greece
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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