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Evaluating Metabolic and Anti-inflammatory Effect of Genistein on Post-myocardial Infarction Patients

RecruitingNAAges 18 Years - anyAllNational Taiwan University Hospital
NCT06689566 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn if genistein works to provide a beneficial effect to show lipid lowering effect and anti-inflammatory effects and slow the progression of atherosclerosis in post-myocardial infarction adults. It will also learn about the safety of genistein. The main questions it aims to answer are: Does genistein lower triglyceride in participants? What medical problems do participants have when taking genistein? Researchers will compare the baseline, under treatment and washout period triglyceride, hsCRP to see if genistein works to decrease inflammation. Participants will: Take genistein every day for 3 months with a fixed dose manner. Afterwards, there will be 3 months washout period. Visit the clinic once every month for checkups and tests. Keep a diary of their symptoms.

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📋 Eligibility rules (as published)
Inclusion criteria 1. Written informed consent. 2. Age ≥ 18 years. 3. History of spontaneous myocardial infarction at least 28 days before recruitment. 4. hsCRP ≥ 0.1 mg/dL 5. BMI ≥ 27 Exclusion criteria 1. Pregnant or nursing (lactating) women 2. Women of child-bearing potential 3. Planned coronary revascularization (PCI or CABG) 4. Major non-cardiac surgical or endoscopic procedure within past 6 months 5. Symptomatic patients with Class IV heart failure (HF) (New York Heart Association \[NYHA\]. 6. Uncontrolled hypertension 7. Uncontrolled diabetes 8. History or evidence of active tuberculosis (TB) infection 9. Patients with prior history of carotid angioplasty, stenting, or carotid atherectomy 10. BMI \> 40 kg/m2 11. Active cancer under treatment
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What it tests

  • genistein
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Where

1 site
National Taiwan University Hospital
Taipei, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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