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Physiologic Effects of Continuous Positive Airway Pressure and High Flow Nasal Oxygenation in Patients with Acute Respiratory Distress Syndrome.

RecruitingNAAges 18 Years - 80 YearsAllRicard Mellado Artigas
NCT06694311 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The acute respiratory distress syndrome (ARDS) consists on a lack of breath due to fluid overload in the lungs that is not produced by a heart desease. Some people with this condition may need to be intubated and connected to invasive mechanical ventilation, but less severe cases may need supplementary oxygen that can be delivered with non-invasive devices, such as CPAP (continuous positive airway pressure) or HFNO (high flow nasal oxygenation). CPAP consists on a facemask that provides oxygen-enriched air at a high pressure, whereas HFNO consists on nasal cannula that provides oxygen-enriched air at a high flow. Patients with ARDS may present with high respiratory efforts that can eventually damage their own lungs and contribute to the development of a phenomenon known as patient self-inflicted lung injury (P-SILI). Previous research has identified that CPAP may be successful in attuen

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📋 Eligibility rules (as published)
Inclusion Criteria: * PaO2/FiO2 ratio \<300 mmHg with FiO2 \>40% and PEEP ≥5 cmH2O (CPAP) or flow ≥30 L/min (HFNC). * Bilateral pulmonary opacities observed in the chest X-ray, thoracic computerized tomography (CT) scan or lung ultrasonography (bilateral B lines) * \<7 days from the pulmonary insult to symptom onset and criteria 1 and 2 * Not meeting the aforementioned criteria for \>24 hours prior to study inclusion. Exclusion Criteria: * Age \<18 years or \>80 years * History of chronic respiratory failure or interstitial pulmonary disease * Acute cardiogenic pulmonary edema after echocardiographic evaluation * Having received either invasive mechanical ventilation or non-invasive mechanical ventilation (NIV) * Atelectasis, pleural effusion, pulmonary masses or nodules as the primary finding in thoracic imaging. * "Do not intubate, do not resuscitate" orders * Presenting significant nasal obstruction.
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What it tests

  • CPAP
  • HFNO 50 L/min
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Where

1 site
Hospital Clínic de Barcelona
Barcelona, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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